I’ll take a crack at the requal aspect.
Easy answer is Yes and more. When you replace the HEPA filter assembly, the HVAC will respond depending on how it was designed. Static systems (usually cheaper to install) are set (velocity/airflow are constant) and left alone with the assumption that they will maintain the complete environment as set. When you replace a HEPA, the response of the system may (or more likely, will) change, hence not only do you need to requalify the room, but the entire system will need to be rebalanced since the resistance will have changed (HEPA are not exact for exact). Since the rooms will change, the cascade effect will change, so rebalancing is needed.
Even for systems with partial (dynamic) control, you would need to rebalance the entire system to ensure it is operating as designed.
Even when a system is completely dynamic (completely automated), you would be best served to ensure it is operating as expected (proper airflow and pressure).
As pointed out with the EM program (expected to demonstrate that you are ensuring the controlled environment), if you are maintaining control spaced (Grade 1, Class 100, ISO 5…or any similar classification), you need to ensure that you are maintaining those conditions.
So when you do replace the HEPA, you need to requalify the area and also address the deviation (that’s another story) and add a CAPA to address the filter failure.
If it was physical damage done by personnel or equipment, then your CAPA may address ways to protect the filters. If was just usage, then you may want to enhance the PM program since you will become painfully aware, that the back trace the use of that area to all manufacturing until the last known good state is going to be no fun. If you do have an EM program, then you are partially saved since you can use your daily/weekly EM data to show that, even with the failure, that there were no harmful effects of the failure to your containment.