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Forced degradation

i’m doing analytical method validation for oral solutions for this solutions thermal degradation is required or not?

Yes.You have to carry out Thermal degradation studies for Solutions.
Dr.Barve

sir,
already i was performed thermal degradation as per our sop and protocol.in that study i was observed,sample volume was decrase and assay was comming above specification lomit.

[quote=prince]sir,
already i was performed thermal degradation as per our sop and protocol.in that study i was observed,sample volume was decrase and assay was comming above specification lomit.[/quote]

Please elloborate your question and briefly share your methodology, so that i can comment on it.

thanks