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Matrix effect

Dear member,

               What is matrix effect? How it is performed ? and what is its acceptance criteria?

[quote=hirenjv]Dear member,

               What is matrix effect? How it is performed ? and what is its acceptance criteria?[/quote]

Dear Hirenj
If u mean specificty then also check Forum
http://www.askaboutvalidation.com/forum/showthread.php?t=279

To check the Matrix effect a placebo is run to check any interference from product excepients. No peak shud interfere wid the active peak analyte or it shud not have same retention time as that of active ingredient.

Dear Hirenjv,

[right][left]The combined effect of all components of the
sample other than the analyte on the measurement of the quantity.
If a specific component can be identified as causing an effect then this is
referred to as interference.[/left][/right]