Just wanted to know opinions -
For potent compounds sampling from bulk containers, if one decides to build a separate room, what should be the pressurization of that room? Positive to the outside area or negative to outside area? The outside area is a Warehouse which has HVAC supplied air. The room does not have separate AHU, but has fan powered HEPA filters to supply air. Moreover, sampling will be performed under Ventilated Balance System (Negative air pressure to the room).
Following situations need to be taken into consideration -
- Room is positive to the warehouse - If the material spills inside the room, the air will carry it into warehouse area.
- Room is negative to the warehouse - If there is no anti room (material air lock) the room will pull dirty air from the warehouse.
- Room has two air locks, one for personnel and one for material transfer. The room is negative to both airlocks (airlocks are bubble out) - In case of spillage, the air inside the room remains inside the room