Please see the attachment.
The role of referecne standard(RS) and Working standard(WS) is same. i.e for the Identificaiton and Quantification of analytes.
But the qualification style is difference from one another.
RS Carries few extensive test like UV, NMR, MS along with the official tests and specifications.
Where as WS Carries only official tests in specifications only(STP)
Instead of RS , WS is useful for daily usage.
Usually we buy RS from Pharmacopieas like USP, BP,IP., we get low quantity from them and the cost of material is very high.
Eg: each 200 mg vial 50,000 rupees.
This much less material is not sufficient to the daily analysis and needs to buy when ever it is exhausted. which is a costly affair.
due to these reasons, Normally we qualify ws against RS.
Then this WS is used for dialy analysis.
Bujji Reddy kanchi.
handling_and_use_of_reference_standards_in_the_omc.pdf (344.3 KB)